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Identification of the plasma proteomic changes of Coronavirus disease 2019 (COVID-19) is essential to understanding the pathophysiology of the disease and developing predictive models and novel therapeutics. We performed plasma deep proteomic profiling from 332 COVID-19 patients and 150 controls and pursued replication in an independent cohort (297 cases and 76 controls) to find potential biomarkers and causal proteins for three COVID-19 outcomes (infection, ventilation, and death). We identified and replicated 1,449 proteins associated with any of the three outcomes (841 for infection, 833 for ventilation, and 253 for death) that can be query on a web portal (https://covid.proteomics.wustl.edu/). Using those proteins and machine learning approached we created and validated specific prediction models for ventilation (AUC>0.91), death (AUC>0.95) and either outcome (AUC>0.80). These proteins were also enriched in specific biological processes, including immune and cytokine signaling (FDR < 3.72x10-14), Alzheimer's disease (FDR < 5.46x10-10) and coronary artery disease (FDR < 4.64x10-2). Mendelian randomization using pQTL as instrumental variants nominated BCAT2 and GOLM1 as a causal proteins for COVID-19. Causal gene network analyses identified 141 highly connected key proteins, of which 35 have known drug targets with FDA-approved compounds. Our findings provide distinctive prognostic biomarkers for two severe COVID-19 outcomes (ventilation and death), reveal their relationship to Alzheimer's disease and coronary artery disease, and identify potential therapeutic targets for COVID-19 outcomes.

Child welfare (CW) agencies use risk assessment tools as a means to achieve evidence-based, consistent, and unbiased decision-making. These risk assessments act as data collection mechanisms and have further evolved into algorithmic systems in recent years. Moreover, several of these algorithms have reinforced biased theoretical constructs and predictors because of the easy availability of structured assessment data. In this study, we critically examine the Washington Assessment of Risk Model (WARM), a prominent risk assessment tool that has been adopted by over 30 states in the United States and has been repurposed into more complex algorithms. We compared WARM against the narrative coding of casenotes written by caseworkers who used WARM. We found significant discrepancies between the casenotes and WARM data where WARM scores did not not mirror caseworkers' notes about family risk. We provide the SIGCHI community with some initial findings from the quantitative de-construction of a child-welfare algorithm.CCS Concepts: • Human-centered computing → Human-computer interaction (HCI); Empirical studies in HCI ; • Applied computing → Computing in government.