Background The higher burden of post‐caesarean infection in the remote Kimberley region of Australia is intimately associated with poorer social determinants of health. This results in a confluence of environmental factors such as overcrowding and limited access to clean water and host factors such as diabetes mellitus and obesity which result in heightened susceptibility and vulnerability to infection. Aim To ascertain infection rates following caesarean section in Broome Hospital, before and after the implementation of evidence‐based strategies intended to reduce bacterial load and mitigate the impact of poor underlying social determinants of health. Materials and methods This is a retrospective observational longitudinal audit study including women who underwent caesarean section in Broome Hospital between the time of 1 January 2019 and 1 May 2019 or 1 January 2021 and 1 May 2021. Files and theatre records were audited to determine demographic, surgical and post‐partum infection in women who underwent caesarean section at Broome Hospital. The main outcome measure was infection within six weeks post‐caesarean section. Results This study found a statistically significant improvement in post‐operative infection rates in women who underwent caesarean section at Broome Hospital (41.7% vs 11.6%, P = 0.002). The two groups were statistically similar in background. Conclusion The combination of various infection prevention initiatives targeted at reducing infection burden can result in clinical and statistically significant reductions in post‐caesarean infections in high‐risk populations with poor underlying social determinants of health.