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This paper proposes the combination of cascade generalization and duo output neural network based on feedforward backpropagation neural networks for cancer prediction. Duo output neural network is a neural network that is created based on two opposite targets in order to predict two opposite results. Cascade generalization is a technique that consists of a set of machines that are sorted together in which the predicted output produced from the previous machine plus the original training input are used for the creation of each machine. In this study, cascade generalization is organized in two levels: the base level and the meta level. In this research, duo output neural network is trained in each level of cascade generalization. Two outputs produced from the base level which are truth output and non-falsity output are averaged. The average result plus the original input are used for training a machine in meta level. The proposed technique is tested using two cancer datasets from UCI machine learning repository and found that our technique provides the best overall results when compared with three individual techniques.