The accumulation of beta-2-microglobulin (beta2M) in collagen-rich tissues has been proven to be the main cause of dialysis related amyloidosis. However, it remains uncertain which technique for the removal of beta2M can be used without compromising the advantages of other dialysis strategies. A new concept, an immunoadsorption wall, which combines the principles of immunoisolation and immunoadsorption is proposed to remove beta2M. The present investigations suggested that the application of the concept to clinical use is feasible and worthwhile. The concept, if validated, will help shape a novel multitask type of artificial kidney based on the combination of different separation technologies.

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Beta-2-microglobulin (P2M) is associated with amyloidosis. The study of P2M kinetics can provide information on the elimination of this uremic toxin. A P2M kinetic model modified from Gotch, considering the volume changes between intracellular, interstitial, and intravascular compartments and the generation stimulation and inhibition during hemodialysis is proposed. The clinical experiments on 8 stable hemodialysis patients treated with polysulfone (F80) and polymethyl methacrylate (PMMA, BK2.lp) 3 times a week were conducted. There was an 18% decrease of P2M clearance in the period from 30 to 180 min with a time-averaged P2M clearance of 48 ml/min using polysulfone dialyzers (F80). In PMMA dialyzers,