The concept of Industry 4.0 has been developed a lot from a theoretical point of view. However, the real applications on production lines remain few in number, due to the difficulties of interoperability between the different production entities and also due to the lack of a control system adapted to the expected flexibility and to the management of the data generated. This article focuses on the development and deployment of a manufacturing execution system (MES) on a production system 4.0. The development stages of the system are explained in detail. The new functionalities and the expected level of performance impose a new logic in the design of advanced systems for controlling and optimizing production. Finally, a proof of concept of an MES was developed and tested on a new technology platform 4.0.