An efficient method for synthesis of 1,3-dimethyl-5-(2-phenyl-4H-chromen-4-ylidene)pyrimidine-2,4,6(1H,3H,5H)-triones has been developed.

A convenient, eco-friendly, and efficient method for synthesis of bis(3-indolyl)methanes by the reaction of indoles with various aromatic aldehydes ''on-water'' has been developed. The attractive features of this method are that in cases of aldehydes which are easily oxidized to acids, no external catalyst is necessary while in other cases a trace amount (ca. 5 mol%) of commercially available and inexpensive catalyst benzoic acid is sufficient to give good to excellent yield of products.

An efficient and ecofriendly synthesis of coumarin-3-carbamides, a class of compounds known for their remarkable biological activities and fluorescent properties, has been developed by a three-component reaction of 2hydroxybenzaldehydes, aliphatic primary/secondary amines and diethyl malonate using Ni-NiO nanoparticless as catalyst in the green solvent ethanol. The method is compatible with various functional groups and moieties.

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An efficient synthesis of 6,12‐methanobenzo[d]pyrano[3,4‐g][1,3]dioxocin‐1(12H)‐ones, a new class of 2,8‐dioxabicyclo[3.3.1]nonanes, starting from 2‐hydroxychalcones or their analogues and 4‐hydroxy‐6‐methyl‐2H‐pyran‐2‐one has been achieved by use of amberlyst‐15, a sulfonated polystyrene resin, as a recyclable heterogeneous catalyst. The methodology involves a domino sequence of Michael addition and two‐stage heterocyclization. Among the synthesized products, two show significant ct‐DNA‐binding properties and all show strong binding with the carrier protein β‐lactoglobulin (β‐lg). A study of antibacterial properties conducted on two bacterial species by using four compounds showed that two of them are moderately active.