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An effective method for the synthesis of highly functionalized isoxazoles from readily available starting ethyl α-nitrocinnamates has been developed. Ethyl α-nitrocinnamates react smoothly with α-nitro carbonyl compounds to produce isoxazoles in good yields. Michael addition of pyridinium ylides to ethyl α-nitrocinnamates can also produce these isox-

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Metal Salt Mediated Radical Reactions of 2-Substituted-1,4-naphthoquinones.-Silver-catalyzed reaction of hydroxymethyl-substituted naphthoquinones (I) with -oxocarboxylic acids (II) provides access towards naphtho-fused furan derivatives (III). In a similar manner, aminomethyl-substituted naphthoquinones (IV) afford naphtho-fused pyrroles (V). Interestingly, manganese-mediated reaction of naphthoquinones (IV) with -keto ester (VI) gives the same naphtho-fused pyrroles (V) instead of the expected naphtho-fused pyridine derivatives. -(LIN, Z.-Y.; CHEN, Y.-L.; LEE, C.-S.; CHUANG*, C.-P.; Eur.

Free radical reactions have become increasingly important in organic synthesis in the last two decades. 1 Compounds containing the quinone group represent an important class of biologically active molecules that are widespread in nature. 2,3 Electrophilic radicals produced from the manganese(III) acetate oxidation of β-dicarbonyl compounds undergo efficient addition to a C-C double bond. 1d,e,4,5 These reactions can be performed intermo-10.