The electrophysiological signature of resting state oscillatory functional connectivity within the default mode network (DMN) during spike-free periods in temporal lobe epilepsy (TLE) remains unclear. Using magnetoencephalographic (MEG) recordings, this study investigated how the connectivity within the DMN was altered in TLE, and we examined the effect of lateralized TLE on functional connectivity. Sixteen medically intractable TLE patients and 22 controls participated in this study. Whole-scalp 306-channel MEG epochs without interictal spikes generated from both MEG and EEG data were analyzed using a minimum norm estimate (MNE) and source-based imaginary coherence analysis. With this processing, we obtained the cortical activation and functional connectivity within the DMN. The functional connectivity was increased between DMN and the right medial temporal (MT) region at the delta band and between DMN and the bilateral anterior cingulate cortex (ACC) regions at the theta band. The functional change was associated with the lateralization of TLE. The right TLE showed enhanced DMN connectivity with the right MT while the left TLE demonstrated increased DMN connectivity with the bilateral MT. There was no lateralization effect of TLE upon the DMN connectivity with ACC. These findings suggest that the resting-state functional connectivity within the DMN is reinforced in temporal lobe epilepsy during spike-free periods. Future studies are needed to examine if the altered functional connectivity can be used as a biomarker for treatment responses, cognitive dysfunction and prognosis in patients with TLE.

This paper proposes an effective elephant flow detection in datacenters. Equal Cost MultiPath (ECMP) is a popular routing mechanism to achieve load balancing in datacenter networks. However, ECMP only considers equally distributing the flows over equal-length paths, but does not take the size of the flows into account. Previous studies show that detecting and rerouting elephant flows (flows that transfer significant amount of data) effectively can lead to a 113% improvement in aggregate throughput compared with the simple use of ECMP. A naive way to detect the elephant flows is to pull statistics from each flow independently. Since "the elephant and mouse phenomenon" suggests that there are only very few elephant flows in a datacenter network, it's not efficient to collect information from each flow. Therefore, we propose a Hierarchical Statistics Pulling (HSP) mechanism using OpenFlow protocol to save bandwidth consumption and processing time. In order to further improve the performance of HSP, two supplement functions called elephant store and range splitting are developed. Our approaches can detect elephant flows with only a small amount of network bandwidth consumption. We use Mininet emulator and mathematical analysis to verify our methods. Both of them confirm the benefits of our approaches.

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Objective To investigate whether interhemispheric functional connectivity (FC) recovers in the first year after total callosotomy. Methods Eight epilepsy patients undergoing total callosotomy were recruited. Resting‐state functional magnetic resonance imaging was acquired before and after surgery. The precallosotomy and postcallosotomy interhemispheric and intrahemispheric FC was analyzed by using graph theory and voxel‐mirrored homotopic connectivity (VMHC). The seizure outcome was scored using the Engel surgical outcome scale. Results After callosotomy (mean postoperative interval = 4 months), the network density, average node degree, characteristic path length, and global efficiency of the whole interhemispheric networks were significantly decreased, compared to those in the precallosotomy networks. However, postcallosotomy interhemispheric FC and homotopic VMHC were not significantly reduced in bilateral frontal and temporal lobes. The network density and average node degree of the intrahemispheric networks were significantly increased. The characteristic path length and global efficiency of intrahemispheric networks were unchanged. Significance The interhemispheric FC may be preserved or recover early within the first postoperative year after total callosotomy, particularly in the frontal and anterior temporal lobes.