Background Subcostal hernia is a type of lateral abdominal wall hernia that usually occurs after open hepatobiliary and esophagogastric operations. The composition of different myofascial layers makes the anatomic reconstruction of the abdominal wall difficult. We aim to evaluate the use of medical glue in fixing the mesh during subcostal hernioplasty compared to sutures. Methods From Jan 2016 to Dec 2021, the data of 58 patients who underwent sublay mesh techniques for subcostal hernioplasty were retrospectively analyzed. The patients were divided into two groups. In the glue group, a combination of a titanium-coated mesh and Compont gel were applied in 12 patients for mesh fixation; In the suture group, a standard polypropylene mesh or composite mesh was fixed by sutures in 14 patients. The operation features, and peri- and postoperative outcomes were analyzed statistically. Meanwhile, medical costs were calculated and evaluated. Results No difference between the two groups was observed concerning demographic characteristics, and operation features such as defect size, and mesh size used for operation. In the follow-up period, there was no difference between the two groups for recurrences, or other complications, such as chronic pain, foreign body sensation, infection of the abdominal wall, and seroma. During hospitalization, the operation time was significantly shortened in the glue group (78.9 ± 20.4 minutes vs 100.8 ± 37.5 minutes, P = 0.043), while the medical costs are comparable between the two groups (P > 0.05). Conclusion The use of Compont gel in fixing the mesh during subcostal hernia repair is associated with a shortened operation time and is convenient, safe, and effective. They are worthy of clinical application.

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