This study optimized and proposed a Warren truss slot-hole structure with a double-sided, square shallow slot and vertical and horizontal corrugated symmetry, achieved with inclined holes based on the stability and a good bearing capacity of an inclined strut truss structure. The tetrahedral truss lattice cells were obverse and reverse-staggered in the central core of the structure. Compared with the double-sided, square shallow groove cylindrical straight hole, the resin consumption of the Warren truss slot holes was similar to that of a vacuum-assisted resin infusion; however, the external flat compression force of the Warren truss slot holes on the resin stiffener structure doubled, and its bending contact force increased by approximately 1.5 times. Furthermore, the resulting Warren truss-slotted resin structure exhibited a late failure time. Compared with the double-sided, square shallow groove cylindrical straight hole foam-core sandwich composite, the Warren truss slot resin-stiffener-reinforced sandwich composite exhibited an increase of 4.7 kN in the flat compression load, an improvement of ~40% in flat compressive strength performance, an increase of ~0.58 kN in the bending load, and an improvement of ~60% in the bending strength, demonstrating its better bearing strength performance.