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Two lanthanide coordination polymers (CPs) {[Er­(Hmtbd)­(H2mtbd)­(H2O)3]·2H2O} n (1) and [Yb­(Hmtbd)­(H2mtbd)­(H2O)3] n (2) carrying an N-heterocyclic carboxylate ligand 5-(3-methyl­formate-1H-1,2,4-triazole-1-methyl)­benzen-1,3-dicarboxy­late (H3mtbd) were prepared under solvothermal conditions. The single-crystal X-ray diffraction data demonstrate that 1 and 2 are isostructural and display 1D chain structure. Alternating current (AC) impedance measurements illustrate that the highest proton conductivities of 1 and 2 can attain 5.09 × 10–3 and 3.09 × 10–3 S·cm–1 at 100 °C and 98% relative humidity (RH), respectively. The value of 1 exceeds those of most reported lanthanide-based crystalline materials and ranks second among the described Er-CPs under similar conditions, whereas the value for 2 is the highest proton conductivity among the previous Yb-CPs. Coupled with the structural analyses of the two CPs and H2O vapor adsorption, the calculated E a values help to deduce their proton conductive mechanisms. Notably, the N-heterocyclic units (triazole), carboxyl, and hydrogen-bonding network all play key roles in the proton-transfer process. The prominent proton conductive abilities of both CPs show great promise as efficient proton conductors.

Background: Alzheimer’s disease (AD) and Type 2 Diabetes Mellitus (T2DM) are two of the most common diseases for older adults. Accumulating epidemiological studies suggest that T2DM is a risk factor for cognitive dysfunction in the elderly. In this study, we aimed to dissect the genetic links between the two diseases and identify potential genes contributing the most to the mechanistic link.Methods: Two AD (GSE159699 and GSE28146) and two T2DM (GSE38642 and GSE164416) datasets were used to identify the differentially expressed genes (DEGs). The datasets for each disease were detected using two platforms, microarray and RNA-seq. Functional similarity was calculated and evaluated between AD and T2DM DEGs considering semantic similarity, protein-protein interaction, and biological pathways.Results: We observed that the overlapped DEGs between the two diseases are not in a high proportion, but the functional similarity between them is significantly high when considering Gene Ontology (GO) semantic similarity and protein-protein interactions (PPIs), indicating that T2DM shares some common pathways with AD development. Moreover, we constructed a PPI network consisting of AD and T2DM DEGs, and found that the hub gene SLC2A2 (coding transmembrane carrier protein GLUT2), which connects the most DEGs in both AD and T2DM, plays as a key regulator in linking T2DM and AD via glucose metabolism related pathways.Conclusion: Through functional evaluation at the systems biology level, we demonstrated that AD and T2DM are similar diseases sharing common pathways and pathogenic genes. SLC2A2 may serve as a potential marker for early warning and monitoring of AD for the T2DM patients.

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To solve the problem that the voltage and current of power consumption in key areas of urban distribution networks exceed the safe range of power consumption, research on power consumption security in key areas of urban distribution networks is carried out. Under the condition of the feeder N-1 criterion, the maximum power supply capacity model of the urban distribution network is established. The theory of feeder interconnection is introduced to determine the security region of the distribution network. The security response is carried out for power users in key areas, and a new power security scheme is proposed. The example proves that the application of the safety guarantee scheme can control the voltage and current in the key areas of urban distribution networks within a safe range, and improve the overall operation safety of urban distribution networks.