Graphical Abstract Highlights d Retina has 2 microglia pools differing by niche and IL-34 dependency d In homeostasis, IL-34-dependent microglia contribute to neuronal function d In degeneration, both pools relocate toward the retinal pigmented epithelium (RPE) d This transition reprograms microglia and is associated with RPE protection
A pathologic role of higher TC or cholesterol-based differential survival of epsilon 4-carrying individuals may be involved in the relationship of the epsilon 4 allele with AD. The observed association of the APOE genotype and AD is expected to depend on the age, sex, and TC distributions of a given sample.
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