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Objective: This study aimed to evaluate the psychometric properties of the Chinese version of the Clinically Useful Depression Outcome Scale (CUDOS). Methods: One hundred ninety patients with major depressive disorder (MDD) according to Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria were recruited to the study. The English version of the CUDOS was translated into Chinese using a forward and backward translation method, which was according to the guidelines of adaptation and validation of instruments in cross-cultural health care research. The Chinese version of the CUDOS, the 17-item Hamilton Rating Scale for Depression (HRSD) and the improved Clinical Global Impression-Severity Scale (iCGI-S) were used to evaluate depressive symptoms in one hundred ninety patients with MDD. One week after the first evaluation, sixteen patients were selected randomly for a second assessment. Reliability and validity tests and receiver operating characteristic curves were performed. Results: The internal consistency of the CUDOS was 0.95, and the split-half reliability coefficient of the CUDOS was 0.92. The correlation coefficient of the retest in sixteen patients was 0.77 (P < 0.01). There was a significant difference in the total score of the Chinese version of the CUDOS between the different levels of depression severity groups (P < 0.01). The ability of the CUDOS to identify patients in remission was high (area under ROC curve= 0.97). A cut-off score of 14/15 yielded 90.20% sensitivity and 93.60% specificity when iCGI-S=1. Conclusion:The Chinese version of the CUDOS is valuable as a brief and reliable instrument to assess depressive symptoms and clinical outcome. The findings suggest that the optimal cut-off score to identify patients in remission was 14/15.

Increasing evidence indicates that immune system dysfunction affects anti‐N‐methyl‐D‐aspartate receptor ( NMDAR ) encephalitis. This study aims to investigate the relationship between adhesion molecules and the pathophysiology in anti‐ NMDAR encephalitis. Soluble forms of Intercellular adhesion molecule‐1 ( sICAM ‐1), vascular adhesion molecule‐1 ( sVCAM ‐1), and L‐selectin ( sL ‐selectin), were measured in the CSF and serum of 26 participants with anti‐ NMDAR encephalitis, 11 patients with schizophrenia and 22 patients with noninflammatory disorders. CSF levels of sICAM ‐1, sVCAM ‐1 and sL ‐selectin were significantly elevated in the anti‐ NMDAR encephalitis group. sVCAM ‐1 levels were positively associated with modified Rankin scale score in anti‐ NMDAR encephalitis patients at the onset and 3‐month follow‐up.