Coronavirus disease 2019 (COVID-19) has been associated with the rare, yet potentially fatal, condition known as epiglottitis. Epiglottitis has the potential to lead to complete airway obstruction, and often constitutes emergent management. Here, we describe a case of acute epiglottitis in a 19-year-old man infected with COVID-19 with a past history of angioedema. We discuss the management of this emergent condition, as well as the differential diagnosis and various management complexities inherent in patients presenting with epiglottitis in this new age of the COVID-19 pandemic.