An unprecedentedly straightforward electro-oxidative coupling of sulfide with activated methylene compound to synthesize sulfur ylide has been developed. Good to excellent yields can be obtained under catalyst- and oxidant-free conditions...

Annulation π-extension of arenes with alkynes is a straightforward and practical strategy for the rapid construction of polycyclic aromatic compounds. Recently, some intriguingly transition-metal-catalyzed polycyclic arene syntheses were described. However,...

A straightforward synthesis of azaheterocycles has been developed through electrochemically aerobic oxidation cyclization using a user-friendly undivided electrolytic cell at room temperature under catalyst-free conditions. This green and practical electrosynthesis strategy features good functional group, diverse electronic and steric properties tolerance. On the basis of a series of mechanistic investigations, including isotope labeling, singlet oxygen inhibiting, superoxide radical anion inhibiting, radical-trapping, cyclic voltammetry and controlled potential electrolysis experiments, a possible N-centered radical-initiated mechanism was proposed.

A straightforward one-pot two-step electrosynthesis of cinnoline derivatives from ortho-alkynyl acetophenones and sulfonyl hydrazides has been developed through the organocatalytic cascade radical cyclization and migration. This methodology features green and mild reaction conditions, good to excellent yield, broad functional group tolerance, excellent regioselectivity, and use of readily available substrates. Moreover, based on isotope labeling, radical trapping, singlet oxygen and superoxide radical anion inhibiting, cyclic voltammetry, and EPR experiments, a possible electrochemically cascade radical cyclization and migration process was proposed.