Background: Cellular senescence plays a complicated and vital role in cancer development because of its divergent effects on tumorigenicity. However, the long non-coding RNAs (lncRNAs) associated with tumor senescence and their prognostic value in hepatocellular carcinoma (HCC) remain unexplored.Methods: The trans-cancer oncogene-induced senescence (OIS) signature was determined by gene set variation analysis (GSVA) in the cancer genome atlas (TCGA) dataset. The OIS-related lncRNAs were identified by correlation analyses. Cox regression analyses were used to screen lncRNAs associated with prognosis, and an optimal predictive model was created by regression analysis of the least absolute shrinkage and selection operator (LASSO). The performance of the model was evaluated by Kaplan-Meier survival analyses, nomograms, stratified survival analyses, and receiver operating characteristic curve (ROC) analyses. Gene set enrichment analysis (GSEA) and cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT) were carried out to explore the functional relevance and immune cell infiltration, respectively.Results: Firstly, we examined the pan-cancer OIS signature, and found several types of cancer with OIS strongly associated with the survival of patients, including HCC. Subsequently, based on the OIS signature, we identified 76 OIS-related lncRNAs with prognostic values in HCC. We then established an optimal prognostic model based on 11 (including NRAV, AC015908.3, MIR100HG, AL365203.2, AC009005.1, SNHG3, LINC01138, AC090192.2, AC008622.2, AL139423.1, and AC026356.1) of these lncRNAs by LASSO-Cox regression analysis. It was then confirmed that the risk score was an independent and potential risk indicator for overall survival (OS) (HR [95% CI] = 4.90 [2.74–8.70], p < 0.001), which outperforms those traditional clinicopathological factors. Furthermore, patients with higher risk scores also showed more advanced levels of a proinflammatory senescence-associated secretory phenotype (SASP), higher infiltration of regulatory T (Treg) cells and lower infiltration of naïve B cells, suggesting the regulatory effects of OIS on immune microenvironment. Additionally, we identified NRAV as a representative OIS-related lncRNA, which is over-expressed in HCC tumors mainly driven by DNA hypomethylation.Conclusion: Based on 11 OIS-related lncRNAs, we established a promising prognostic predictor for HCC patients, and highlighted the potential immune microenvironment-modulatory roles of OIS in HCC, providing a broad molecular perspective of tumor senescence.

This study examines oral tissue color in Uygur and Han Chinese populations. The color of oral tissues is of great significance in dental field. It remains uncertain whether there is any difference in the color of oral tissues between different nationalities or ethnicities. Little is known about the color of oral tissues in different Chinese populations. The study included 263 Uygur and Han students aged 18-22 years. The color of anterior teeth, vermilion, and attached gingiva in the subjects was measured by spectrophotometry and expressed through the CIELCh system. The t test and ANOVA was used to analyze color difference between groups. Distribution ranges for L à ab (lightness), C à ab (chroma) and h à ab (hue angle) of anterior teeth, vermilion, and attached gingiva in these two ethnicities were obtained. Significant differences in color of oral tissues between Uygur and Han Ethnicities were found out. The Uygur and Han populations have similar spatial distribution ranges for the color of oral tissues, with slight differences that displayed strong regularities, suggesting that the color of oral tissues was associated with race. In addition, there was a trend of decreasing lightness (especially for maxillary anterior teeth), increasing chroma and redder hue from the center of teeth toward the sides in both ethnicities. There were differences in the color of teeth and attached gingiva between sexes in the Uygur and Han populations. The color of the upper vermilion differed significantly from that of the lower vermilion.

The application of solar-driven interface evaporation photothermal materials in the complex water environment is facing great challenges, and the development of multifunctional photothermal materials is great significance to the practical application process. In this study, a new kind of photothermal material was first prepared based on the natural pumices, which shows great advantages of lightweight, superhydrophilicity, porous property, and heat insulation. To improve its light absorption capacity and photocatalytic effect, carbon and Ag + were uniformly loaded on pumices (named P-C-Ag + ). The as-resulted P-C-Ag + shows an evaporation rate of 1.395 kg m À2 h À1 which refers to an evaporation efficiency of 88.80% in simulated seawater under 1 kW m À2 illumination. In the rooftop experiment, the cumulative evaporation capacity of the simulated solar evaporator with P-C-Ag + in 8 hours can reach about 7.25 kg m À2 . Meanwhile, almost no salt crystallization was found in the surface of P-C-Ag + during the continuous evaporation process. The P-C-Ag + has a good inhibitory effect on Escherichia coli and algae, and can degrade color dyes, which is also beneficial to water environment, thus holding great potential as multifunctional photothermal material for solar steam generation and water treatment.

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