Over the past few decades, optical waveguides have been increasingly used in wearable/implantable devices for onbody sensing. However, conventional optical waveguides are stiff, rigid, and brittle. A mismatch between conventional optical waveguides and complex biointerfaces makes wearable/implantable devices uncomfortable to wear and potentially unsafe. Soft and stretchable polymer optical waveguides not only inherit many advantages of conventional optical waveguides (e.g., immunity to electromagnetic interference and without electrical hazards) but also provide a new perspective for solving the mismatch between conventional optical waveguides and complex biointerfaces, which is essential for the development of light-based wearable/ implantable sensors. In this review, polymer optical waveguides' unique properties, including flexibility, biocompatibility and biodegradability, porosity, and stimulus responsiveness, and their applications in the wearable/implantable field in recent years are summarized. Then, we briefly discuss the current challenges of high optical loss, unstable signal transmission, low manufacturing efficiency, and difficulty in deployment during implantation of flexible polymer optical waveguides, and propose some possible solutions to these problems.