Purpose To meet the requirement of establishing an effective schedule for the assembly process with overall detection and rework, this paper aims to address a new problem named resource-constrained multi-project scheduling problem based on detection and rework (RCMPSP-DR). Design/methodology/approach First, to satisfy both online and offline scheduling, a mixed integer programming model is established with a weighted bi-objective minimizing the expected makespan and the solution robustness. Second, an algorithm that combines a tabu search framework with a critical chain-based baseline generation scheme is designed. The tabu search framework focuses on searching for a reasonable resource flow representing the execution sequence of activities, while the critical chain-based baseline generation scheme establishes a buffered baseline schedule by estimating the tradeoff between two aspects of bi-objective. Findings The proposed algorithm can get solutions with gaps from −4.45% to 2.33% when compared with those obtained by the commercial MIP solver CPLEX. Moreover, the algorithm outperforms four other algorithms in terms of both objective performance and stability over instances with different weighting parameters, which reveals its effectiveness. Originality/value The represented RCMPSP-DR considering the overall detection and rework is an extension of the scheduling problem for large-scale equipment. An effective algorithm is proposed to establish the baseline schedule and determine the execution sequence of activities for the assembly process, which is significant for practical engineering applications.

Succinate is widely used in the food and feed industry as an acidulant, flavoring additive, and antimicrobial agent. This study investigated the effects of dietary succinate on growth, energy budget, nutritional metabolism, protein succinylation, and gut microbiota composition of zebrafish. Zebrafish were fed a control-check (0% succinate) or four succinate-supplemented diets (0.05, 0.10, 0.15, and 0.2%) for 4 weeks. The results showed that dietary succinate at the 0.15% additive amount (S0.15) can optimally promote weight gain and feed intake. Whole body protein, fat, and energy deposition increased in the S0.15 group. Fasting plasma glucose level decreased in fish fed the S0.15 diet, along with improved glucose tolerance. Lipid synthesis in the intestine, liver, and muscle increased with S0.15 feeding. Diet with 0.15% succinate inhibited intestinal gluconeogenesis but promoted hepatic gluconeogenesis. Glycogen synthesis increased in the liver and muscle of S0.15-fed fish. Glycolysis was increased in the muscle of S0.15-fed fish. In addition, 0.15% succinate-supplemented diet inhibited protein degradation in the intestine, liver, and muscle. Interestingly, different protein succinylation patterns in the intestine and liver were observed in fish fed the S0.15 diet. Intestinal proteins with increased succinylation levels were enriched in the tricarboxylic acid cycle while proteins with decreased succinylation levels were enriched in pathways related to fatty acid and amino acid degradation. Hepatic proteins with increased succinylation levels were enriched in oxidative phosphorylation while proteins with decreased succinylation levels were enriched in the processes of protein processing and transport in the endoplasmic reticulum. Finally, fish fed the S0.15 diet had a higher abundance of Proteobacteria but a lower abundance of Fusobacteria and Cetobacterium. In conclusion, dietary succinate could promote growth and feed intake, promote lipid anabolism, improve glucose homeostasis, and spare protein. The effects of succinate on nutritional metabolism are associated with alterations in the levels of metabolic intermediates, transcriptional regulation, and protein succinylation levels. However, hepatic fat accumulation and gut microbiota dysbiosis induced by dietary succinate suggest potential risks of succinate application as a feed additive for fish. This study would be beneficial in understanding the application of succinate as an aquatic feed additive.

No abstract

No abstract