The results indicate that ivermectin may inhibit LPS-induced production of inflammatory cytokines by blocking NF-kB pathway and improve LPS-induced survival in mice. This finding might provide a new strategy for the treatment of endotoxemia and associated inflammation.

The rate of brucellosis, a zoonotic disease, has rapidly increased in humans brucellosis(HB) in recent years. In 1950–2018, a total of 684,380 HB cases (median 2274/year (interquartile range (IQR) 966–8325)) were reported to the National Infectious Disease Surveillance System in mainland China. The incidence of HB peaked in 2014 (4.32/100,000), and then showed a downward trend; we predict that it will maintain a steady downward trend in 2019–2020. Since 2015, the incidence of HB has shown opposite trends in the north and south of China; rates in the north have fallen and rates in the south have increased. In 2004–2018, the most significant increases in incidence of HB were in Yunnan (IQR 0.002–0.463/100,000), Hubei (IQR 0.000–0.338/100,000), and Guangdong (IQR 0.015–0.350/100,000). The areas where HB occurs have little overlap with areas with high per capita GDP in China. The “high–high” clusters of HB are located in northeastern China (Inner Mongolia, Heilongjiang, Jilin, Liaoning, Ningxia, Shanxi, and Gansu), and the “low–low” clusters of HB are located in southern China (Yunnan, Jiangxi, Shanghai, Guangxi, Guangdong, Zhejiang, Guizhou, and Hunan). In recent years, the incidence of HB in China has been controlled to some extent, but the incidence of HB has increased in southern China, and the disease has spread geographically in China from north to south. Further research is needed to address this change and to continue to explore the relationship between the incidence of HB and relevant factors.

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To ensure the safe operation of CNC machines, a fault diagnosis strategy based on cascading failure is proposed. According to fault mechanism analysis, a directed graph model of fault propagation between components in machine tool systems is established. In this study, the interpretative structural model method is used to realize the hierarchical structure of fault propagation model by matrix transformation and decomposition. Subsequently, the PageRank algorithm is introduced to evaluate the failure effects of the machine tool system components. The Johnson method is then applied to correct the component fault sequence and establish the model of rate of occurrence of failures that is based on time correlation. Finally, the fault diagnosis strategy is formulated through the component rate of the occurrence of failure, fault influence and fault propagation model, to identify the main cause of the fault and provide the basis for fault diagnosis. In the end, a machine tool equipment is used as an example for application to verify the validity of the method.

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