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The overall objective of this study was to examine the effects of an innovative culturally appropriate school‐based intervention. Cherokee Talking Circle (CTC), for the prevention of substance use among 100 Keetoowah‐Cherokee 6th graders as they transition to middle school. The impact of the CTC on substance use involvement (measured by the Global Assessment of Individual Needs – Quick) and Cherokee self‐reliance (measured by the Cherokee Self‐Reliance Questionnaire) was assessed using a two‐condition quasi‐experimental design, comparing the CTC to standard substance use education (SE). Findings from this study suggest that prevention from a cultural perspective is an obvious course of action against substance use among Native American early adolescents.

This article traces the development of a research project with a Native American community. Four principles were used to guide the development of the “Community Partnership to Affect Cherokee Adolescent Substance Abuse” project using a community-based participatory research approach. The principles suggest that establishing trust is key when developing and conducting research with a Native American community.

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