Objectives: This study was evaluated the association of serum means platelet volume, functional outcome and various parameters in patients of ischemic stroke. Methods: Detail history clinical examinations and relevant investigations were performed to all subjects. Lab parameters included as platelets counts, mean platelet volume and others were performed. The diagnosis of ischaemic stroke was made clinically with the evidence of acute lesions (infarct) confirmed by brain CT or MRI within the first 24 h of presentation of symptoms. Each patient condition was assessed by modified Rankin Scale. Results: Data was analyzed using SPSS version 26 software. Related-Samples Wilcoxon Signed Rank Test was applied. Mean and standard deviation were calculated. P value was taken less than or equal to 0.05 for significant differences (p ≤ 0.05). Conclusions: There was no significant difference seen in platelet count of ischemic stroke cases with control. Mean platelet volume was significantly higher in ischemic stroke cases than normal subjects. Majorities of ischemic stroke cases had moderate disability, required some help but able to walk without assistance. MPV was higher in ischemic stroke cases that had higher Modified Rankin scale.  Hence, serum MPV can be used as meaningful laboratory findings for early detection of ischemic stroke. Key words: Ischemic stroke, mean platelet volume, platelet count, modified Rankin score

Objectives: This present study was to evaluate the clinical profile and prevalence of non motor symptoms in Parkinson’s disease patients on the basis of various system involvements. Methods: Detail history, clinical examination and relevant investigations were performed to all cases of Parkinson’s disease patients. The diagnosis of Parkinson’s disease was confirmed by UKPDS Brain Bank Criteria. Neurological examination was conducted for MMSE scores and H and Y staging. Results: Data was analyzed by using simple statistical methods with help of Ms-Office software. Data was tabulated and percentages were calculated. Conclusions: Parkinson’s disease was commonly occurred in old age male populations. Most of the cases had H & Y stage 2. Non motor symptoms were progressed as the stage of Parkinson’s disease progressed. Nausea, unsatisfactory bowel voiding and constipation were common gastrointestinal symptoms. Decreased libido, orthostatic hypotension, nocturia and hypo/hyper Sexuality were common autonomic dysfunction. Insomnia, Restless Leg and Behavioural limb movements were common sleep disorders. Dementia, attention deficit, anhedonia and apathy were common neuropsychiatric symptoms seen in patients with Parkinson’s disease. Common sensory symptoms were unexplained Pain (Paraesthesia) and hyposmia. Other common symptoms of Parkinson’s disease patients had swelling of leg, falls and weight gain. Hence early diagnosis, management and awareness are essential for improvement of quality of life of patients with Parkinson’s disease. Keywords:  Parkinson’s disease, non motor symptoms, Hoehn & Yahr stage, UKPDS Brain Bank Criteria

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