Although microtubule-associated serine/threonine kinase-like (MASTL) is a promising target for selective anticancer treatment, MASTL inhibitors with nano range potency and antitumor efficacy have not been reported. Here, we report a novel potent and selective MASTL inhibitor MASTL kinase inhibitor-2 (MKI-2) identified in silico through a drug discovery program. Our data showed that MKI-2 inhibited recombinant MASTL activity and cellular MASTL activity with IC50 values of 37.44 nM and 142.7 nM, respectively, in breast cancer cells. In addition, MKI-2 inhibited MASTL kinase rather than other AGC kinases, such as ROCK1, AKT1, PKACα, and p70S6K. Furthermore, MKI-2 exerted various antitumor activities by inducing mitotic catastrophe resulting from the modulation of the MASTL-PP2A axis in breast cancer cells. The MKI-2 treatment showed phenocopies with MASTL-null oocyte in mouse oocytes, which were used as a model to validate MKI-2 activity. Therefore, our study provided a new potent and selective MASTL inhibitor MKI-2 targeting the oncogenic MAST-PP2A axis in breast cancer cells.

Most of the research on three-dimensional interaction field have showed different accuracy in terms of sensing, mode and method. Furthermore, implementation of interaction has been a lack of consistency in application field. Therefore, this study is to suggest research trends of three-dimensional interaction using meta-analysis. Searching relative keyword in database provided with 153 domestic papers and 188 international papers covering three-dimensional interaction. Analytical coding tables determined 18 domestic papers and 28 international papers for analysis. Frequency analysis was carried out on method of action, element, number, accuracy and then verified accuracy by effect size of the meta-analysis. As the results, the effect size of sensor-based was higher than vision-based, but the effect size was extracted to small as 0.02. The effect size of vision-based using hand motion was higher than sensor-based using hand motion. Therefore, implementation of three-dimensional sensor-based interaction and vision-based using hand motions more efficient. This study was significant to comprehensive analysis of three-dimensional motion recognition for interaction and suggest to application directions of three-dimensional interaction.

This study was to suggest the proper level of touch sensibility for twenties while flicking touch phones. A rapid prototype of 480×800 pixel size was developed for the experiment. Participants were 20 undergraduates, not visually and physically handicapped in using touch phones. 15 different modes, with each mode changing in velocity when flicking the prototype were randomly presented to each subject. The subjects were asked to score what they felt in each mode on a 1-to-6 Likert scale. The data was analyzed by the one-way ANOVA procedure. Each mode showed significant differences in 8 representative emotions except for exclusivity feeling and fresh feeling. Each velocity mode was scaled by the multidimensional scaling technique. Then, vector coordinates in each emotion were obtained by simple regression analysis. 15 velocity modes and each emotion were joint-plotted by the MDS, PROXSCAL. The findings in this study could be basic data for studying affective touch sensibilities in multiple ways.

Firefighters are constantly exposed to dangers in disaster sites and they need a plan to safeguard their mental health. There are various programs in place, such as mental and physical health stabilization rooms, to reduce stress and prevent mental illnesses. While these are easily accessible during work, they are lacking in function. To effectively decrease the stress of firefighters, a beam projector set, a speaker, a LED lamp were installed in an independent booth, called a activity healing room. Such rooms were built in fire stations and its effects on stress were analyzed. The indicator was based on measurement of a respiration rate and a heart rate. Additionally, for the qualitative analysis, mental health interviews of firefighters confirmed stress reduction. The results of this study are expected to be used as baseline data to enhance psychological resilience in firefighters and to revitalize their mental and physical health using stabilization rooms.

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