This paper describes a microcontroller-based multichannel telemetry system, suitable for in vivo monitoring of physiological parameters. The device can digitalize and transmit up to three analog signals coming from different sensors. The telemetry transmission is obtained by using a carrier frequency of 433.92 MHz and an amplitude-shift keying modulation. The signal data rate is 13 kb/s per channel. The digital microcontroller provides good flexibility and interesting performance, such as the threshold monitoring, the transmission error detection, and a low power consumption, thanks to the implementation of a sleep mode. The small overall size (less than 1 cm3), the power density compatible with current regulations for the design of implantable devices, and the dedicated packaging make the system suitable for in vivo monitoring in humans. The design, fabrication, operation, packaging, and performance of the system are described in this paper. An in vivo pressure monitoring case study is described as well.

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The adoption of Industry 4.0 technologies is slow and lacks homogeneity across the manufacturing landscape. Challenges arise from legacy IT systems, or a low level of digitization leading to difficult integration processes, or simply the fear of investing too much in building the necessary infrastructure versus the uncertainty of the potential benefits. The market has also become more demanding, both in terms of competition and customer requirements, so that more and more manufacturers are faced with the demand for high production flexibility, high quality, and low operating costs. This paper aims to address the implementation complexity of a cyber-physical production system for zero-defect manufacturing in dynamic, high-value, high-mix, and low-volume contexts where the level of digitalization is still low, or the IT infrastructure is rigid.