Introduction:The AIMS 65 score is a new bedside score proposed for the assessment of liver function which is simple and more independent. Different scores have been recommended to predict outcomes in the setting of upper gastrointestinal bleeding (UGIB), limited comparative studies have been published between simplified versions of older scores and recent scores. In this present study, we aimed to retrospectively compare the performance of AIMS 65 score with Child-Pugh score, MELD score and ALBI score for predicting the outcome in patients with upper GI bleed in chronic liver disease. Material and Methods:Data of patients with chronic Liver disease secondary to ethanol were retrospectively reviewed. Child Pugh score, MELD score, ALBI score and AIMS 65 score were calculated for the patients and results . ROC curves derived from comparison with outcome and were analysed. Results:In our study conducted on 112 patients, the age distribution was between 20-85 years with mean age of patients being 46.47 ± 10.9 years, sex ratio Male: Female: 105:7 with mortality rate of 33.92%. The Area under curves of ROC of AIMS65, Child Pugh score, MELD score, ALBI score was 0.779, 0.864, 0.763 and 0.777 respectively.Conclusion: AIMS 65 is a simple and non-endoscopic score for the prediction of in hospital mortality. No statistical difference was observed between AIMS-65 and other scores such as Child Pugh score, ALBI and MELD score.How to cite this article: Nagaraja BS, Madhumathi R, Chidananda V, Sanjeet SB,Abhiman Shetty, Mahadev H Malge. A comparative study of AIMS 65 score with other scoring systems to predict outcomes in patients with upper GI bleed in chronic liver disease.