Background:We previously reported that Kgp, a lysine gingipain, degraded osteoprotegerin, an osteoclastogenesis inhibitory factor, to enhance lipopolysaccharide-induced osteoclastogenesis. Results: Kgp enhanced tumor necrosis factor-␣-and interleukin-1␤-induced osteoclastogenesis. Conclusion: Kgp degraded osteoprotegerin more efficiently than other cytokines, which might be related to enhancement of osteoclastogenesis by Kgp. Significance: Degradation of osteoprotegerin may be a crucial event in periodontal osteolysis.

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