No abstract

This approach facilitates dissection of the IPDA on the right side of the SMA, thereby reducing operative times.

BackgroundThe aim of the present study was to investigate the feasibility of resection based on the nerve and fibrous tissue (NFT) structures around the superior mesenteric artery (SMA) for resectable pancreatic adenocarcinoma (R‐PDAC) patients.MethodsNFTs around the SMA were classified into four “intensive NTFs area” with spreading the NFTs around the SMA and three SMA nerve plexus regions without branching nerves according to autopsy findings. Complete dissection of four “intensive NTFs areas” was performed by pre‐exposing three SMA nerve plexus regions without branching nerves as “dissection‐guiding points” with SMA nerve plexus preservation (NFT‐based resection). Among 157 R‐PDAC patients undergoing pancreaticoduodenectomy, surgical outcomes of 78 patients with NFT‐based resection were compared with 59 patients with half‐SMA nerve plexus dissection and 20 patients without NFTs dissection.ResultsIn the NFT‐based resection group, 76.5% had tumor involvement and metastasis in each intensive NTFs area. Operative time, blood loss, and postoperative diarrhea rate were significantly lower in NFT‐based resection than in half‐SMA nerve plexus group (321 vs 390 min; P < .01, 228 vs 550 mL; P < .01, 5.1% vs 15.3%; P = .04, respectively). R0 rate and median overall survival significantly improved in NFT‐based resection than in non‐NFT dissection group (93.6% vs 65.0%; P < .01, 49.6 vs 23.6 months, P = .01).ConclusionNFT‐based resection may become a novel method for R‐PDAC patients.

Concurrent IMRT with gemcitabine and S-1 for patients is feasible as NACRT for BR-A with low gastrointestinal toxicity. IMRT can be employed as a standard radiotherapy to provide more effective NACRT with powerful chemotherapy drugs.

Pancreaticoduodenectomy with PDJV resection is feasible for PDAC with PDJVI and satisfactory overall survival rates are achievable. It may be necessary to reconsider the resectability of PDAC with PDJVI.