Objec&ve:To assess the prevalence of oral mucosal lesions in pa3ents with pemphigus and pemphigoid diseases from Southern India. Design and Methods: A cross--sec$onal hospital based study was conducted from August 2010 to July 2011. Pa(ents with confirmed pemphigus and pemphigoid skin disease were selected and informed to par(cipate in the study. Oral examina2on of all par2cipants were done to document site and type of oral manifesta3on and diag--nos$c procedures such as histopathological and Immunofluorescence methods were performed to confirm the diag--nosis. Demographic details such as age, gender and occupa5on were also documented. The results of the study were analyzed by SPSS so.ware version 19.0 (Armonk, NY) and presented as descripBve staBsBcs. Results: Sixty percent of the pa'ents exhibited oral mucosal manifesta'ons. A higher female (86.66%) predilec'on of autoimmune blistering disease was observed in the study. A slightly higher number of pemphigoid pa8ents (53.33%, 16 out of 30) were re--ported than pemphigus (46.66%, 14 out of 30 cases). The most common subtypes of pemphigus is Pemphigus vulgaris 71% (10 out of 14) among pemphigus, and bullous pemphigoid 87.5%(14 out of 16) among pemphigoid. Buccal muco--sa (92.85%) is the most common site in pemphigus pa7ents, where as hard palate (12.5%) is mostly commonly re--ported site in pemphigoid pa/ents. Ini/al involvement of oral 'ssue in disease process was observed in 78.57% of pemphigus, and 12.5% of pemphigoid pa5ents. Conclusion: Oral mucosal lesions are more frequently associated in pemphigus pa+ents. Oral mucosal lesions are the ini+al site of disease process in pemphigus pa+ents. The significance of diagnosis of oral lesions at earlier stage of disease, specifically pemphigus may help in early interven7on of disease and help to reduce the morbidity and mortality state. The study emphasizes mul6disciplinary approach in diagnosis and management of both pemphigus and pemphigoid.Cita%on: Santosh, et al. (2017) Oral mucosal lesions in pa/ents with pemphigus and pemphigoid skin diseases: a cross sec1onal study from southern India.

The underlying oral manifestations and co-morbidities could become very important variables that must be taken into account in determining treatment efficacy or health policy.