An 8-yr-old, male brush-tailed porcupine (Atherurus macrourus) presented for necropsy examination in good nutritional status. It had received treatment for Strongylus spp. infection 1 yr earlier, and it had a short episode of diarrhea 2 days before death. Postmortem examination revealed disseminated, variably discrete, soft to firm, white-gray nodules over the omentum, mesentery, intestinal serosa, and at the liver surface. Histologically, these tumors were mainly arranged as proliferating spindle cells growing in interlacing fascicles or in a storiform pattern associated with ropy collagenous stroma and vascularization. Inflammatory cells, consisting of lymphocytes, plasma cells, and macrophages, infiltrated between the tumor cells. Cytoplasmic immunoreactivity of antibodies to alpha-smooth muscle actin and vimentin was observed in the tumor cells. Antidesmin immunoreactivity varied with area. The morphologic features, the presence of inflammatory infiltrates, and the immunohistochemical expression were consistent with a diagnosis of inflammatory myofibroblastic tumor as reported in humans, horses, and cats.

Abstract.A case of fibrosarcoma with lung and lymph node metastases in a 54-year-old female Asian elephant (Elephas maximus) is described. After pododermatitis of 2 years duration in the right forefoot, a mass developed in the lateral toenail. At postmortem, metastasis to the right axillary lymph node and both lungs was noted. Microscopic examination of primary and metastatic sites revealed infiltrating bundles of spindle cells, with fairly distinct cell borders, variable amounts of eosinophilic cytoplasm, and elongate or oval nuclei. Tumor cells were often arranged in interwoven bundles and herringbone patterns. Mitotic figures were numerous and frequently bizarre. The diagnosis of fibrosarcoma with lung and lymph node metastases was made on the basis of histologic features and positive immunohistochemical staining for vimentin.A 54-year-old female Asian elephant (Elephas maximus) housed at the Taipei Zoo in North Taiwan had a 2-year history of pododermatitis of the right forefoot. The lesion had been treated by surgical debridement, irrigation with 5% Povodine iodine, and soaking using 5% copper sulfate solution. Clinical signs had slowly improved, the lesion resolved, but in the next 6 months a rapidly growing mass developed proximal to the lateral toenail of the previous site of pododermatitis. The mass was red-black and cauliflower-shaped with a necrotic and irregular hemorrhagic skin surface (Fig. 1). The animal was lame in the affected foot. A biopsy was performed under general anesthesia, and histologic evaluation indicated a sarcoma with necrotic foci and an ulcerative surface. The tumor cells stained positive for vimentin and negative for cytokeratin (AE1/AE3), desmin, smooth muscle ␣-actin, S-100, and factor VIII-related antigen. The animal died after 3 days recumbency.Necropsy revealed marked swelling of the right forefoot due to the mass with an ulcerative and cauliflower-shaped appearance. The tumor was approximately 34 ϫ 24 ϫ 10 cm 3 and was more extensive than it had appeared on external inspection. On the transverse section, the tumor was white, firm, and multilobulate with multifocal hemorrhage and necrosis in the soft tissue under the skin. The tumor had metastasized to the right axillary lymph node; the area was extremely swollen. The metastatic lesion was 12 ϫ 7 ϫ 2 cm 3 , firm, multilobulate, with multiple areas of necrosis on the cut section. Multiple nodules, 0.5-5 cm in diameter, were present in both lungs. The cut surface of nodules was graywhite and glistening. Postmortem radiography of the lungs

Abstract.A 12-year-old female American badger was presented to the Taipei city zoo veterinary ward with anorexia and weakness. Treatments were ineffective, and the badger died of chronic interstitial nephritis and uremia. At necropsy, numerous firm white nodules, measuring 0.5-2.0 cm, were present on the surface of the liver, stomach, spleen, small intestine, pancreas, and diaphragm. Most nodules were encapsulated and well demarcated from the organs to which they were attached. A poorly demarcated mass, measuring 0.5 cm in diameter, had invaded the hepatic parenchyma and appeared to be the origin of all the nodules derived by transcavitary implantation. Histologically, the nodules contained primarily oval or spindle-shaped cells, typical of smooth muscle cells, forming alternating bundles attached to the surface of the various organs. In some nodules, aggregates of individual polyhedral to round cells with round to oval centrally located nuclei and abundant eosinophilic cytoplasm, typical of smooth muscle origin, were noted. Zones of subcapsular necrosis and multifocal necrosis were also observed in some nodules. Tumor cells stained positively for ␣-smooth muscle actin and vimentin and negatively for desmin, cytokeratin, estrogen, and progesterone receptors. This tumor is similar to but distinguishable from the ''disseminated peritoneal leiomyomatosis (DPL)'' found in women. Leiomyosarcoma is a slow-growing malignant tumor of smooth muscle origin found primarily in the uterus, liver, spleen, cecum, small intestine, and stomach, as well as in the urinary bladder, heart, and deep soft tissues of domestic animals. 5,7 The muscular layer of these organs is usually involved. All dogs with leiomyosarcomas of the liver have visible metastasis; 7 however, peritoneal metastasis is rarely reported. Although the presence of epithelioid leiomyoma (leiomyoblastoma, leiomyosarcoma) is common in humans, it has been reported rarely in domestic or wild animals. 3,4 We report herein a case of epithelioid leiomyosarcoma occurring in the visceral peritoneum of an American badger (Taxidea taxus).A 12-year-old female American badger was presented for treatment of anorexia and weakness. Physical examination revealed penetrating wounds on her back, as well as old unhealed wounds on the right metatarsal area. Palpation also revealed unusual masses in the abdominal cavity. Supportive treatments were ineffective, and the animal died of chronic interstitial nephritis and uremia. A necropsy was performed.Grossly, there was a 40-ϫ 25-cm area of suppurative cellulitis on her back associated with the penetrating wound. Valvular endocardiosis associated with age was present. The kidneys were firm and granular and had tubular cysts, consistent with chronic nephritis and uremia seen clinically. In addition, firm white nod-