The classification of electroencephalography (EEG) signals is one of the most important methods for seizure detection. However, verification of an atypical epileptic seizure often can only be done through long-term EEG monitoring for 24 hours or longer. Hence, automatic EEG signal analysis for clinical screening is necessary for the diagnosis of epilepsy. We propose an EEG analysis system of seizure detection, based on a cascade of wavelet-approximate entropy for feature selection, Fisher scores for adaptive feature selection, and support vector machine for feature classification. Performance of the system was tested on open source data, and the overall accuracy reached 99.97%. We further tested the performance of the system on clinical EEG obtained from a clinical EEG laboratory and bedside EEG recordings. The results showed an overall accuracy of 98.73% for routine EEG, and 94.32% for bedside EEG, which verified the high performance and usefulness of such a cascade system for seizure detection. Also, the prediction model, trained by routine EEG, can be successfully generalized to bedside EEG of independent patients.

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