A readily available chiral Brønsted acid was identified as an efficient catalyst for intramolecular Povarov reactions. Polycyclic amines containing three contiguous stereogenic centers were obtained with excellent stereocontrol in a single step from secondary anilines and aldehydes possessing a pendent dienophile. These transformations constitute the first examples of catalytic enantioselective intramolecular aza-Diels-Alder reactions.

A readily available chiral Brønsted acid was identified as an efficient catalyst for intramolecular Povarov reactions. Polycyclic amines containing three contiguous stereogenic centers were obtained with excellent stereocontrol in a single step from secondary anilines and aldehydes possessing a pendent dienophile. These transformations constitute the first examples of catalytic enantioselective intramolecular aza-Diels-Alder reactions.

Synthesis and Reactivity of 2,3-Dihydro-1H-pyrrolo(1,2-a)indole Derivatives, Analogues of the FR900482 and Mitomycin C Active Intermediates.-A series of the title pyrroloindoles are synthesized as analogues of the active intermediates of the natural products mitomycin C and FR900482, and their reactivity toward various nucleophiles is studied. -(ZHANG, W.; LOCURCIO, M.; LIN, C.-C.; JIMENEZ, L. S.; J. Heterocycl.

Catalytic Enantioselective Intramolecular Aza-Diels-Alder Reactions. -Highly annulated heterocycles are obtained via intramolecular Povarov reaction promoted by a readily available chiral Broensted acid catalyst. These are the first examples of catalytic enantioselective intramolecular aza-Diels-Alder reactions. -(MIN, C.; LIN, C.-T.; SEIDEL*, D.; Angew. Chem., Int. Ed. 54 (2015) 22, 6608-6612, http://dx.doi.org/10.1002/anie.201501536 ; Dep. Chem. Chem. Biol., Rutgers State Univ. N. J., Piscataway, NJ 08854, USA; Eng.) -H. Haber 38-030