Prior methods in characterizing age-related white matter hyperintensity (WMH) lesions on T 2 fluid-attenuated inversion recovery (FLAIR) magnetic resonance images (MRI) have mainly been limited to understanding the sizes of, and occasionally the locations of WMH lesions. Systematic morphological characterization has been missing. In this work, we proposed innovative methods to fill this knowledge gap. We developed an innovative and proof-of-concept method to characterize and quantify the shape (based on Zernike transformation) and texture (based on fuzzy logic) of WMH lesions. We have also developed a multi-dimension feature vector approach to cluster WMH lesions into distinctive groups based on their shape and then texture features. We then developed an approach to calculate the potential growth index (PGI) of WMH lesions based on the image intensity distributions at the edge of the WMH lesions using a region-growing algorithm. High-quality T 2 FLAIR images containing clearly identifiable WMH lesions with various sizes from six cognitively normal older adults were used in our method development Analyses of Variance (ANOVAs) showed significant differences in PGI among WMH group clusters in terms of either the shape ( P = 1.06 × 10 −2 ) or the texture ( P < 1 × 10 −20 ) features. In conclusion, we propose a systematic framework on which the shape and texture features of WMH lesions can be quantified and may be used to predict lesion growth in older adults.