Introduction:Although traditional medicines are widely used, quality and safety of some of them are not ensured due to lack of suitable quality controls and inadequate labeling. he diagnostic cellular structures and cell content for all powdered ingredients in Khurtsiin deed-6 traditional medicine were defined by "Novel" light microscopy. Biologically active compounds were identified by using TLC and HPLC. Main biologically active compounds contents were determined by UV spectrophotometer methods. Some quality and safety parameters of Khurtsiin deed-6 traditional medicine were determined by Mongolian National First Pharmacopoeia methods. Results: Some quality and safety parameters of the traditional medicine were determined as: moisture 9.63±0.09%, total ash 4.725±0.22%, and water-soluble extractive 21.28±0.11%, Alcohol soluble extractive total 46.30±0.09%, aerobic microbial count 5x10 3 , total yeast and mold count 3x10 2 . The fingerprints of TLC and HPLC to reveal gallic acid, apigenin, costunolide, E-guggulsterone were defined. The total contents were measured for phenolic compounds as 65.95±1.05 mg/g and for flavonoids as 10.55 ±0.16 mg/g. Conclusion: The standardization criteria for Khurtsiin deed-6 traditional medicine were defined and Mongolian National Pharmacopeia Monograph's draft for Khurtsiin deed-6 traditional medicine was developed.