A cute myocardial ischemia and infarction are frequently the outcomes of the underlying etiology, coronary artery blockage (AMI) which is a notable cause of death in developed nations (Hundahl et al., 2017). The identification of a possible "cardio-safe" new chemical entity (NCE) depends heavily on cardiac electrophysiology in the animal model as well as in vitro and silico studies (De Clerck et al., 2002). It is well known that the infusion of BaCl 2 promotes the development of arrhythmia by causing prolonged depolarization and triggering activity via rises in Na + and Ca 2+ influx to the heart. The presence of K + in the external solution may be impeded by the penetration of Ba 2+ through the K + channel, which could increase the auto-rhythmicity of the heart and result in ventricular arrhythmia, according to electrophysiological investigations. This is the most important finding (Kehl et al., 2013;Rowley and Roux, 2013). The therapeutic advantages of nonapeptide BK have been demonstrated in several clinical and experimental trials, and they extend beyond the treatment of hypertension and congestive heart failure (Ozer et al., 2002). Since BK circulates at extremely low concentrations (1 to 50 fmol/mL) and is quickly digested by kininases,