A green protocol for one-pot synthesis of pharmacologically important indolyl chromenes and bis(indolyl)alkanes was achieved using Saccharomyces cerevisiae (commonly known as bakers' yeast) as catalyst under room temperature stirring condition. This method is relatively simple, efficient, inexpensive, and environment-friendly.
Biologically important pyrazoloquinolinone and triazoloquinazolinone derivatives were synthesized by the condensation reaction of 3-amino-1H-1,2,4-triazole/3-amino-5-methyl-1H-pyrazole, dimedone and aryl aldehydes using catalytic amount of magnetically retrievable nickel nanoparticles under reflux condition. This protocol eliminates the usage of toxic reagents, complex work-up conditions, etc., with the added benefit of reusability of the catalyst without compromising the yield or purity of the product.
Results and discussionOur present work deals with the synthesis of triazoloquinazolinones/pyrazoloquinolinones through a simple method in
A green and facile method for the alkylation of indole/substituted indole in water using a phase Transfer catalyst (Triethylbenzylammonium Chloride, TEBA) to synthesise bis‐indolyl methanes (BIMs) and Michael addition of indole to α,β‐unsaturated carbonyl compounds is reported. The substitution of indoles occurred exclusively at the 3‐position and products of N‐alkylation has not been observed. However, for 3‐substituted indoles, reactions were found to occur at the 2‐position. A comparative study between conventional heating and microwave irradiation has also been reported.
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