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Background: The aim is to study the correlation of serum uric acid and atrial fibrillation in hypertensive individuals and the effect of duration of hypertension on atrial fibrillation & serum uric acid (SUA). Materials and Methods: Patients (age between 35-65years) were selected from outpatient OPD & IPD. A control group of 100 non hypertensive individuals and another group of 100 hypertensive patients were enrolled. Serum uric acid, Echocardiography: A Trans Thoracic Echocardiography (TTE) measurement of Left atrium diameter (LVST), interventricular septal thickness (LVPWT), posterior wall thickness, left ventricular end diastolic diameter (LV) and LV ejection fraction (LVEF) was recorded. Results: Hyperuricemia incidence in controls was 11% and hyperuricemia incidence in cases was 65 %. The incidence of hyperuricemia in cases with phase 1 of hypertension was 6.27±1.22 mg/dl and those with phase 2 of hypertension was 7.59±1mg/dl which was significant. Atrial fibrillation incidence was 4% in the hypertensive patients and the atrial fibrillation incidence in normotensive patients was 1%. Conclusion: Hypertension duration had a significant effect on the SUA levels and revealed that there was noteworthy increase in the SUA level in individuals with atrial fibrillation than those without atrial fibrillation.

Background: Hyponatremia develops in early phases of acute myocardial infarction, recently, several studies showing its importance as important early prognostic tool. Many studies shown that significant increase in plasma AVP level was in patients who had associated with complication as heart failure and fatal outcome after acute MI, and clinical improvement was noted following the rise in serum plasma level of sodium. hence Early developed hyponatremia is a unique indicator of neuro hormonal activity in the early phases of recent MI, so it can help predict the complication as long-term development of HF and death. OBJECTIVE: To observe the prognostic importance of hyponatremia in settings of acute STEMI event and helpfulness in prediction of short term and long term survival. Subjects and Methods: Randomized double blinded study, in 100 of patients with acute S TEMI presented to outpatient department and indoor emergency patients. Results: Patients who developed hyponatremia at admission had higher mortality rate than the patients who developed hyponatremia at 72 hrs and normonatremic patients. Mortality in patients correlates with the severity of hyponatremia 5(100%) patient died with sodium levels <130mmol/l whereas 5(16%) death occurred in the patient having sodium level between 131-134. (Odds ratio 6.0, p value 0.02). Conclusion: We concluded that hyponatremia developed in early as well as late phases of acute STEMI serve as is an 'independent determinant of both short term (in hospital mortality, development of arrhythmias and heart failure) as well as long term survival (cardiac death, post discharge heart failure). Plasma sodium levels may help identify patient at risk.

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