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Aim: The aim of this study was to examine the impacts of different (non-clinical) risk factors on the populations’ predisposition to tropical diseases specifically Malaria, yellow fever, typhoid fever, chicken pox, measles, hepatitis B and UTI.Subject and Methods: Data for this study was obtained through patient diagnosis forms, distributed to physicians in Nigeria. A total of 2199 patient consultation forms were returned by 102 (out of 125) physicians, and considered useful for analysis. Demographic data of patients, physicians, and diagnosis outcomes were analysed descriptively through frequency distributions, aggregate analysis, and graphs, while the influence of risk factors on the disease manifestations (diagnosis outcomes) were determined using regression analysis.Results: Findings from our study demonstrated that the difficulty in diagnosing tropical disease was associated with significant increase in morbidity and mortality especially in patients with malaria, UTI and typhoid fever. Factors such as contact with an infected person and poor personal hygiene posed significant risk, while urbanization and homelessness, posed very low risks across all the diseases. Conclusion: The risk factors identified in our study exert differential and discriminating influences in the causation, predisposition, and transmission of these conditions, understanding the individual risk factors for each condition have significant socio-economic implications for people living in tropical and endemic regions, especially with respect to management and prevention of these conditions.