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These factors might reveal a new insight into the complex pathogenesis of PCOS especially with respect to cAMP pathway.

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Natural killer cells (NK cells) are increasingly explored for adoptive cancer immunotherapy. Like T cells, NK cells can be genetically modified to express chimeric antigen receptors (CARs) that recognize tumor-associated cell surface antigens and mediate selective recognition and specific lysis of cancer cells, thereby overcoming endogenous resistance mechanisms in tumor cells. In two previous phase I clinical trials, the continuously expanding human NK cell line NK-92 has been safely applied as an allogeneic cell therapeutic with clinical responses observed in some of the cancer patients treated. To enhance efficiency and specificity, the ErbB2-specific cell clone NK-92/5.28.z was generated, which carries a codon-optimized CAR (CAR 5.28.z) based on ErbB2-specific antibody FRP5 and CD28 and CD3ζ signaling domains. Elevated ErbB2 (HER2) protein levels have been reported in a significant proportion of GBM tumors and were correlated with impaired survival. In preclinical studies, we could demonstrate high and specific activity of NK-92/5.28.z cells against established and primary ErbB2-positive glioblastoma cells. In orthotopic xenograft models in immunodeficient mice repetitive intracranial injections of NK-92/5.28.z cells led to a highly extended symptom-free survival. In an immunocompetent mouse model, repetitive intratumoral NK-92/5.28.z injections induced an endogenous immune response against syngeneic GL261/ErbB2 glioblastomas. This resulted in tumor rejection and long-term protection against tumor rechallenge. Based on these promising data, we designed the CAR2BRAIN trial (EudraCT number 2016-00025-39), a monocentric phase I dose finding trial investigating the safety and tolerability of NK-92/5.28.z cells as an allogeneic cell therapeutic in patients with recurrent glioblastoma. The NK-92/5.28.z cells will be injected during relapse surgery into the resection wall (dose escalation cohort; 9-18 patients), and in a second patient group repetitively through a Rickham reservoir into the resection cavity (expansion cohort; 6 patients). In the dose escalation part of the trial the highest cell number which can be applied safely will be established (maximum tolerated dose = MTD) with a maximum dose of up to 1x10^8 cells planned. After determination of the MTD in the dose escalation cohort, in addition to the initial injection into the resection wall up to twelve further injections through the Rickham reservoir will be carried out to establish safety of prolonged treatment in the expansion cohort. Distribution of the injected NK-92/5.28.z cells in the brain, the cerebrospinal fluid and the blood will be monitored. Furthermore, the immune reaction triggered against the target antigen ErbB2 as well as ErbB2-independent immune reactions will be characterized. P07.02 TRIALS OF A PERSONALIZED PEPTIDE VACCINE (ITK-1) FOR PATIENTS WITH RECURRENT OR PROGRESSIVE GLIOBLASTOMA (GBM)T. Fujimaki 1 , K. Itoh 2 , M. Terasaki 2 , Y. Narita 3 , Y. Arakawa 4 , K. Sugiyama 5 , R. Nishikawa 6 , T. Aoki 7 , T. Kumabe 8 , M. Nagane 9 ; ...

In today's world, development in technology has brought social and economic benefits to society and technological devices play a vital role in our day-to-day life. However, with advancement in the field of electronics and communication technology, there is an increased risk of exposure to electromagnetic field and this may cause many health problems in humans as well as affecting the environment. Sources of electromagnetic waves are power transmission line, base transmitter station, mobile phones, household appliances and the waves that are emitted from these sources get absorbed in the body causing various ill-effects. Various studies have shown that radiations from mobile phone/towers increases the rate of various types of cancer among women and children. Electromagnetic radiations can also cause changes in EEG pattern, decrease in TSH, T3, T4, prolactin, testosterone, estrogen and progesterone levels. Experimental studies showed that long- term exposure to electromagnetic waves decrease sperm count and quality among men. RF- EMR can cause DNA damage, affect embryo viability and cause premature birth. In this narrative review, we focus on the available literature describing the ill-effects of various kinds of electromagnetic radiation emitting sources on multiple organs/organ systems of the human body as well as its effect on the environment from studies carried all across the world.