Raman-scattering studies at both ambient pressures and in a high-pressure diamond-anvil cell are used to measure gas-to-liquid vibrational frequency shifts of three normal modes of acetonitrile, CH3CN (ν1, CH stretch; ν2, CN stretch; and ν4, CC stretch) dissolved in various solvents (methylenechloride, chloroform, carbontetrachloride, toluene, pyridine, acetone, and methanol). The results are compared with calculated repulsive and attractive solvation force-induced perturbations of polyatomic vibrational potential surfaces. Repulsive solvation forces are modeled using recently developed analytical ‘‘hard-fluid’’ expressions for heteronuclear two-cavity distribution functions in hard-sphere fluids, while attractive forces are assumed to contribute a van der Waals(linearly density-dependent) mean field. Results for the CN and CC stretches of acetonitrile compare favorably with theoretical predictions, while the CH stretch appears to experience a nonlinearly density-dependent attractive frequency shift at high densities. Empirical attractive frequency-shift parameters, derived from gas-to-liquid shifts at 1 atm, agree reasonably well with those predicted using a simple dispersive and dipolar solvation force expression. Attractive solvation forces are found to correlate well with solvent polarizability (and solute bond polarizability derivatives). Dipolar solvation forces only appear to contribute significantly to the CN stretch.

The anthelmintic effects of flubendazole (methyl [5-(4-fluorobenzoyl)-1-H-benzimidazol-2-yl] carbamate) (Janssen Pharmaceutica) were evaluated in jirds (Meriones unguiculatus) and cats (Felis cattus) infected with Brugia pahangi. Flubendazole was macrofilaricidal at 5 x 2.5 mg/kg and 1 x 25 mg/kg in jirds and 1 x 100 mg/kg in cats when administered by subcutaneous injection. It also killed developing larvae in jirds. It was not microfilaricidal.

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A review was done on 631 patients with acute myocardial infarction who underwent coronary angiography within 30 days after onset of myocardial infarction at Yonsei University Severance Hospital from January, 1985, to August, 1993. The incidence of acute myocardial infarction in patients under 40 years of age was 10.3% (65/631). Acute myocardial infarction below the fourth decades was the predominant disease of men. Risk factor analysis revealed a history of cigarette smoking and hypercholesterolemia were more frequently found in the young patients, but a history of hypertension and diabetes were more frequently found in the elderly patients. Angiographically, the incidence of one vessel disease and normal or minimal lesion coronary anatomy were more frequent in the young patients and incidence of multi-vessel disease were more frequent in the elderly patients. Of the 65 patients under 40 with acute myocardial infarction, the patients with multi-vessel disease tended to have a history of diabetes mellitus in comparison with those with normal coronary anatomy or one vessel disease.