Wound healing is a complex matrix and overlapping process. In order to accelerate the healing process and minimize bacterial infection, lightbased therapy was applied to stimulate bioreaction to improve healing. The aim of this paper is to review the effects induced by light source (laser and incoherent light like LED) on different biological targets. The light based therapy techniques were categorized according to the wavelength, energy density, type of irradiance and activity of tissues in the healing process. Out of 80 cases, 77% were animal studies, 5% were human studies and 18% were cell studies. Around 75% of light based therapy has an advantage on tissue interaction and 25% has no effect or inhibition on the healing process. The appropriate dose appears to be between 1 and 5 J cm −2. At shorter wavelength, photobiostimulation would be effective with a high frequently administrated lowenergy dose. On the other hand, for longer wavelength it is the reverse, i.e., more effective with a low frequent treated schedule and a highenergy dose.

Background: A spike of 5 cases of positive culture fungal endophthalmitis occurred within a period of 30 days in patients with different working diagnosis. Investigations were initiated to look for possible causes/explanation. Results: Five cases with different working diagnosis had positive fungal culture within a period of thirty days. Investigations showed that four out of five sampling were done in the same procedure room, and that all culture plates used were from the same refrigerator in the same procedure room. The procedure room environment was sub-optimal for procedures. A non-functioning air-conditioner created a hot and humid environment. A blowing stand-fan was used to provide air circulation during procedures. Multiple green-black-brownish spots of fungi growth were noticed on the cellulose ceiling board. The infection control team were informed and involved in investigation and rectification process, which include but not restricted to thorough disinfection procedures and air-conditioner repair. There were no longer any clinically inappropriate positive cultures reported following rectification. As patients responded well without/before starting anti-fungal therapy, we strongly believe that the clinically inappropriate positive cultures were due to environmental contamination. Conclusion: Contamination/infection can occur via airborne pathogen transmission especially fungi, thus WHO recommended a level of <50 CFU/m 3 of air in hospital settings. A high level of suspicion should be maintained. Lab results are not absolute and clinical co-relation is of utmost importance in patient's management.