In this study, we developed a pipeline transport model to investigate the influence of particle sedimentation factors on slurry transportation through pipelines. The particle tracking module of the software was used to simulate the transport process, and the influences on the sedimentation rate were analyzed considering the slurry concentration, particle size, and flow velocity. The established model exhibited small calculation errors. In addition, the results revealed that the proposed model is reliable for calculating the degree of influence of various factors on particle sedimentation. The effect of the particle sedimentation rate on the pipeline slurry was explored considering the particle size, slurry concentration, and flow velocity. The sedimentation rate was positively related to particle size and adversely related to the slurry concentration and flow velocity. Indeed, study on the sedimentation rate requires considering a reasonable range of particle sizes, preparing a slurry with an appropriate concentration, and adjusting an appropriate flow velocity. Numerical simulations were performed using the filling data as the background for a sample mining area. The experimental results showed optimal slurry concentration and particle size of 60% and 25.25 µm, respectively.