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Highlights Its a case report of a patient suffering from Unilateral TMJ Ankylosis, Marfan Syndrome & OSA. Surgical intervention is often needed to correct the various deformities affecting the patients to restore the function, improving the patient’s aesthetic appearance and quality of life. This paper highlights the various surgical procedures undertaken to correct the deformities affecting the individual and improving the overall health of the patient. Our patient’s management shows the necessity of a multidisciplinary, multi factorial and multi-faceted approach with early visual identification and diagnosis.