Objective Direct neuronal loss or deafferentation of the putamen, a critical hub in corticostriatal circuits, may result in diverse and distinct cognitive and motoric dysfunction in neurodegenerative disease. Differential putaminal morphology, as a quantitative measure of corticostriatal integrity, may thus be evident in Huntington disease (HD), Alzheimer Disease (AD) and Frontotemporal Dementia (FTD), diseases with differential clinical dysfunction. Method HD (n=17), FTD (n=33) and AD (n=13) patients were diagnosed according to international consensus criteria, and with healthy controls (n=17), were scanned on the same MRI scanner. Patients underwent brief cognitive testing using the Neuropsychiatry unit cognitive assessment tool (NUCOG). Ten MRI scans from this dataset were manually segmented as a training set for the Adaboost algorithm, which automatically segmented all remaining scans for the putamen, yielding the following subset of the data: 9 left and 12 right putamen segmentations for AD; 25 left and 26 right putamina for FTD; 16 left and 15 right putamina for HD; 12 left and 12 right putamina for controls. Shape analysis was performed at each point on the surface of each structure using a multiple regression controlling for age and sex to compare radial distance across diagnostic groups. Results Age, but not sex and ICV, were significantly different in the segmentation subgroups by diagnosis. The AD group showed significantly poorer performance on cognitive testing than FTD. Mean putaminal volumes were HD

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