Background: Muscle injuries are common in humans and are often associated with irrecoverable damage and disability. Upon muscle injury, TNF-α signaling pathways modulate the healing process and are predominantly associated with tissue degradation. In this study we assumed that TNF-α inhibition could reduce the TNF-α-associated tissue degradation after muscle injury. Materials and methods: Therefore, the left soleus muscle of 42 male Wistar rats was injured using a standardized open muscle injury model. All rats were treated immediately after injury either with infliximab (single i.p. injection; 10 mg/kg b.w.) or saline solution i.p. Final measurements were conducted at day one, four, and 14 post injury. The muscle force, the muscle cell proliferation, the muscle cell coverage as well as the myofiber diameter served as read out parameters of our experiment. Results: Systemic application of infliximab could significantly reduce the TNF-α levels in the injured muscle at day four upon trauma compared to saline treated animals. The ratio of muscle weight to body weight was increased and the twitch muscle force showed a significant rise 14 days after trauma and TNF-α inhibition. Quantification of myofiber diameter in the penumbra zone showed a significant difference between both groups at day one and four after injury, indicated by muscle hypertrophy in the infliximab group. Planimetric analysis of the injured muscle at day 14 revealed increased muscle tissue fraction in the infliximab group compared to the control animals. Muscle cell proliferation did not differ between both groups. Conclusions: These data provide evidence that the TNF-α blockade positively regulates the restauration of skeletal muscles upon injury.

Due to antiquated technologies (calculation methods, regulations, lighting and luminaire concepts, production techniques) current outdoor lighting causes a lot of problems like light pollution, glare, energy waste etc.New types of luminaires, and in consequence new outdoor lighting concepts, can be created by combining advanced calculation methods for optical surfaces with recent production technologies and novel light sources such as short arc metal halide lamps. Light emitted from this small Etendue light sources can precisely be redirected by 3D-curved surfaces manufactured with injection molding, milling and aluminium metallization. The required optical design may use techniques like complex surface calculations and 3D-Tailoring.An innovative concept based on the latest findings in visual perception research is to focus the light of such short arc light sources onto a facetted secondary mirror which provides the desired illuminance distribution on a facade or a public place. These systems are designed to fulfill lighting requirements as well as providing visual comfort. Thus lamps with improved color rendering, luminous efficacy and increased lifetime are used and glare is minimized by splitting the reflector into many facets (light spot decomposition).A few examples of realized projects are presented where such complex facetted surfaces are used to reach a special quality of light. Using novel techniques like 3D-Tailoring, each facet can be designed to individually create the desired (e.g. uniform) illuminance distribution on the target surface -in this case, a large facade. For this particular application, we chose to impose a square boundary for each facet, in order to tile the rectangular aperture of the secondary mirror without compromising efficiency.

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