This article investigates the determinants of individual support for independence in Montenegro. We outline five theoretically distinct groups of factors covered by the literature and evaluate their impact on individual preference for independence. Using observational data obtained from a nationally representative survey conducted in Montenegro in 2003–2004, we find support for several hypotheses, showing that identity, income, and partisanship significantly impact individual opinion about independence. We also investigate and discuss the relative effect size of different factors associated with preference for independence. Additionally, we test variables with hitherto unexplored implications for opinions on independence, including the impact of support for EU membership, as well as support for democratic principles. Our logistic regression analyses reveal that attitudes towards EU integration and minority rights are strongly associated with support for independence. By systematically analyzing existing and new hypotheses with data from an understudied case, our findings contribute to the nascent literature on individual preferences for independence.