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Starting from substituted 9-chloroacridines, a series of quinacrine and spacered dimeric acridine compounds was prepared. Their ability to interrupt the protein association of prion- and Alzheimer-specific proteins and Ab peptides was explored using a fast screening system based on FACS analysis. The bis-acridines displayed a higher activity than the corresponding monomers. Among these derivatives, best results were obtained with the 2,4-dimethoxy-6-nitro compound 7h for Abeta-peptides and the 2-methoxy-6-nitro compound 7f for PrP.

The crystal structure of i Pr 4 Sn 4 S 6 consists of isolated molecules that contain an adamantane-like Sn 4 S 6 core. The tin atoms are coordinated nearly tetrahedrally, with Sn-S distances ranging from 2.397 (1) Fig. 1) possesses crystallographic mirror symmetry, with the mirror plane passing through the atoms Sn(1), Sn(2), S(1), S(3), C(1) and C(3). The Sn-S distances (2.397(1)-2.411(1)Å) agree with the values for the Sn 4 S 6 cages cited above. The coordination geometry of the tin atoms is essentially tetrahedral, with S-Sn-S angles ranging from 110.5(1) to 112.8(1)• and C-Sn-S angles between 104.2(2) and 109.2(1)• . Programs used: SHELXL, DIAMOND. CCDC deposition number: 226 390. EXPERIMENTAL

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