These findings demonstrate the feasibility, efficacy and specificity of the anti-AP-1 dODN approach to the treatment of restenosis, which principally but not exclusively targets deformation-induced ET-1 synthesis in the vessel wall. Provided that these findings can be extrapolated to the situation of patients with coronary artery disease, the observed extent of the inhibitory effect of the AP-1 dODN treatment suggests that this co-medication may greatly reduce the incidence of in-stent restenosis.

Abstract. The provision of network Quality-of-Service (network QoS) is a major challenge in the development of future communication systems. Before designing and implementing these systems, the network QoS requirements are to be specified. Existing approaches to the specification of network QoS requirements are mainly focused on specific domains or individual system layers. In this paper, we present a holistic, comprehensive formalization of network QoS requirements, across layers. QoS requirements are specified on each layer by defining QoS domain, consisting of QoS performance, reliability, and guarantee, and QoS scalability, with utility and cost functions. Furthermore, we derive preorders on multi-dimensional QoS domains, and present criteria to reduce these domains, leading to a manageable subset of QoS values that is sufficient for system design and implementation. The relationship between layers is formalized by two kinds of QoS mappings. QoS domain mappings associate QoS domains of two abstraction levels. QoS scalability mappings associate utility and cost functions of two abstraction levels. We illustrate our approach by examples from the case study Wireless Video Transmission.

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A publication by Fraunhofer IESEFraunhofer IESE is an institute of the Fraunhofer Gesellschaft. The institute transfers innovative software development techniques, methods and tools into industrial practice, assists companies in building software competencies customized to their needs, and helps them to establish a competitive market position.