Summary. Inclusion of the BCR±ABL ES probe in routine cytogenetics led to the identification of a subgroup of Philadelphia positive (Ph1) chronic myeloid leukaemia patients characterized by a 5 H -ABL deletion. This anomaly was observed in 5/51 cases (9´8%). Cytological and clinical data suggest that the 5 H -ABL deletion may be associated with dysplastic features of polymorphonuclear cells and metamyelocytes and a short chronic phase duration.

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