College students who have high stress levels tend to experience an increased risk of academic difficulties, substance abuse, and emotional problems. To enhance student stress management and health promoting behaviors, an online stress management intervention called MyStudentBody-Stress (MyStudentBody-Stress) was developed and tested. College students at six U.S. colleges were randomized to one of three conditions: MyStudentBody-Stress, a control health information website, or no intervention. The differences between groups on stress control and health behavior measures were compared at baseline, and at 1, 3, and 6 months after baseline. Although there were no between-group differences on primary outcome variables, secondary analyses indicated that MyStudentBody-Stress participants were more likely to increase weekly physical activity, use specific stress management methods, and exhibit decreased anxiety and family problems. These findings indicate some potentially beneficial effects of online stress management programming for college students. Implications for college health practitioners are discussed.