Ameloblastoma is a benign odontogenic tumor of epithelial origin that exhibits a locally aggressive behavior with a high level of recurrence and multiple factors involved in its molecular pathogenesis.This article is a case report of a 46-year-old male patient suffering from a progressively enlarging tumor of the anterior mandible that caused gradual expansion of the lingual cortical plate and root displacement without resorption of the involved teeth. Incisional biopsy was consistent with "conventional" ameloblastoma, showing a mixed pattern of both the follicular and acanthomatous subtypes. This diagnosis was corroborated through a histopathological examination of the resected specimen. The patient was submitted to en bloc resection (marginal mandibulectomy) with preservation of the lower mandibular border; dental rehabilitation was achieved through a removable prosthesis. He remains disease-free for 5.5 years postoperatively and is highly satisfied with mastication and speech.The objective of this report is to highlight a relatively rare histopathological presentation of the "conventional" ameloblastoma, involving a site not commonly affected by ameloblastomas, the anterior mandible and crossing the midline, in a relatively young male patient.

Introduction: Verrucous carcinoma (VC) of the oral mucosa is a rare type of non-metastatic, low-grade and well differentiated squamous cell carcinoma. The neoplasm is typically presented with a slow and superficial growth in elderly males. Various factors are known to implicate in its pathogenesis and affect the progression and prognosis of the neoplasm. When invasive atypical areas are present, VC is then described as hybrid verrucous carcinoma (HVC). Case Report: A 55-year-old woman was referred with an elevated leukoplakic verrucous lesion on the dorsal surface of the tongue, measuring 2 cm at its maximum diameter. The patient had been a smoker for ten years with no pertinent past medical history. An incisional biopsy had already been performed a month before referral with the histopathology report of an atypical verrucous papillary lesion. An excisional biopsy was performed at the referral and the lesion was resected with a spindle-shaped surgical incision circumcising the neoplasm within safety margins. The final histopathology report made the diagnosis of VC with multiple foci of microinvasive squamous cell carcinoma (verrucous carcinoma – hybrid type). Conclusion: Differential diagnosis of VC still remains a challenge and various clinical, histopathological and immunohistochemical parameters should be considered. The treatment of choice for VC is surgical excision within safety margins. A clinical follow-up should then be scheduled for these patients and they must remain alert for any changes of the oral mucosa for the future.