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in IE rotation (r2¼0.33) and total reaction moments (r2¼0.66). There were no differences in walking speed or step-length for any treatment. Conclusion: The shift towards greater tibia internal rotation and the association with external joint moments suggests that with treatment of Celecoxib there may be a lessening of bracing or co-contraction around the joint that results from pain and inflammation. A rotational shift in joint kinematics has previously been linked with patterns of cartilage thinning. The different kinematic response between the two treatment arms suggest potential differences in the impact of these drugs on ambulation and may have implications for different rates of disease progression that require further study.